Desmopressin is a vasopressin analog that promotes platelet adhesion to the endothelium by increasing the endothelial release of Von Willebrand factor and enhances the activity of platelets. The Guidelines for Reversal of Antithrombotics in Intracranial Hemorrhage from the Neurocritical Care Society and the Society of Critical Care Medicine, and the European Guidelines suggest considering desmopressin in patients with intracranial hemorrhage who were taking antiplatelet agents prior to presentation, despite a paucity of evidence to support use in this setting. The research goal of this project is to determine if desmopressin decreases hematoma expansion in ICH and traumatic brain injury patients across a large number of patients presenting to emergency departments at a number of centers across the United States.
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